23 Genes, 23 years later

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23 Genes, 23 years later

George Palade's pioneering work in the 1960s had established the secretory pathway and its connection to the biogenesis of organelles as a major theme in eukary-otic cell biology (Palade, 1975). His disciples, including David Sabatini and Gunter Blobel, extended Palade's morphological approaches to the next level of analysis, involving subcellular fractionation and biochemical re-constitution t...

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A23 23..23

Three papers in the Journal this month examine the impact on service use of particular service developments and patient/illness characteristics. Williams et al (pp. 480–485) compared patterns of service use, including hospital admission rates, before and after the introduction of a triage admission system in one large innercity mental health organisation. Overall, little difference was found be...

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A23 23..23

Several papers in the BJPsych this month address issues arising from the overlap or comorbidity between mental and physical ill health. In a UK sample of individuals with affective disorders, Forty et al (pp. 465–472) found significantly increased rates of several medical illnesses among those with bipolar and unipolar disorder compared with controls. Among those with affective disorder, migrai...

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A23 23..23

Two papers in the Journal this month examine patterns of prescribing practice. With established clinical guidelines for the management of individuals with treatment-resistant schizophrenia in mind, Howes et al (pp. 481–485) reviewed prescribing practices prior to commencement of clozapine for a sample of patients managed within one mental health service. The authors found evidence of a signific...

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Chapter 23

The remarkable scientific work on fertility preservation that is documented in the early chapters of this volume will inevitably give rise to moral and religious questions about the use of technology to reproduce. In this regard, oncofertility is no different from other forms of assisted reproduction that have led to extensive debate among ethicists and moral theologians. In the case of many fo...

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ژورنال

عنوان ژورنال: Cell

سال: 2004

ISSN: 0092-8674

DOI: 10.1016/s0092-8674(03)00972-3